DNA Vectors
Vector Biolabs AAV-CMV-mCherry (AAV1) AAV (AAV1-mCherry)
This AAV serotype 1 virus (Capsid from AAV1 and ITR from AAV2) expresses mCherry as reporter.The mCherry expression is under the control of CMV promoter.
Vector Biolabs Carnitine O-octanoyltransferase Adenovirus (Ad-CROT)
Carnitine octanoyltransferase is a carnitine acyltransferase that catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine. This provides a crucial step in the transport of medium- and long-chain acyl-CoA out of the mammalian peroxisome to the cytosol and mitochondria.
Vector Biolabs Scramble shRNA (AAV serotype 2) AAV (AAV2-GFP-U6-shRNA)
This AAV expresses a scramble shRNA sequence under the control of U6 promoter, with the GFP co-expression under a CMV promoter. This AAV is a serotype 2 virus (with Capsid from AAV2 and ITR from AAV2)
Vector Biolabs CCAAT/enhancer binding protein (C/EBP), alpha Adenovirus (Ad-C/EBP)
C/EBP (CCAAT-enhancer binding protein) is a heat-stable, sequence-specific DNA-binding transcription factor that was initially purified from rat liver nuclei. C/EBP binds DNA through a bipartite structural motif and appears to function exclusively in terminally differentiated, growth-arrested cells. Additional family members include C/EBP-beta, C/EBP-gamma, C/EBP-zeta and C/EBP-epsilon, all of which exhibit similar DNA-binding specificities and affinities with C/EBP-alpha. Furthermore, C/EBP-beta and C/EBP-zeta readily form heterodimers with each other as well as with C/EBP-alpha.
BIOHIPPO AAV-CMV-EGFP-WPRE-hGH-polyA
Recombinant adeno associated virus expressing EGFP under the CMV promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
BIOHIPPO AAV-U6--shRNA(scramble)--CMV-mCherry-SV40-polyA
Recombinant adeno associated virus expressing shRNA (scramble) fused to mCherry under the U6 CMV promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Vector Biolabs NK2 transcription factor related, locus 5 (Drosophila) Adenovirus (Ad-NKX2.5/CSX)
The Nkx family of homeobox containing transcription factors are differentially expressed and regulate the production of tissue specific target genes. Some members of the Nkx family include TTF-1 (also designated Nkx-2.1), Nkx-2.2, Nkx-2.5 (also designated cardiac specific homeobox protein CSX), Nkx-2.6, Nkx-3.1, Nkx-3.2, Nkx-6.1 and Nkx-6.2. TTF-1 is primarily observed in adult thyroid and lung. Nkx-2.2 and Nkx-6.1 are required for pancreatic B-cell differentiation, and Nkx-2.5 and Nkx-2.6 are involved in normal cardiac development. Nkx-3.1 is predominantly expressed in developing and adult prostate tissue.
Sigma Aldrich Fine Chemicals Biosciences CAS9 Blasticidin Lenti Plasmid, 50 uL vial
This product is a blasticidin resistant lenti-Cas9 plasmid for generation of lentiviral particles. Functional Genomics/Screening /Target Validation/Genome Editing.
Vector Biolabs AAV-CMV-iCre (AAV8) AAV (AAV8-iCre)
Cre recombinase is used as a tool to genetically modify genes, such as to delete a segment of DNA flanked by LoxP sites in cells or experimental animals. By applying the mammalian codon usage to Cre recombinase, expression of Cre is improved in the mammalian cells. This improved Cre (iCre) gene also reduce the high CpG content of the prokaryotic coding sequence, thereby reducing the chances of epigenetic silencing in mammals.This AAV-DJ/8 stock expresses an improved Cre (iCre) driven by one CMV promoter
Vector Biolabs PTPN11 Adenovirus (Ad-PTPN11)
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
BIOHIPPO AAV-CaMKIIa-DO-hChR2(H134R)-EGFP-WPRE-hGH-polyA
Recombinant adeno associated virus expressing hChR2(H134R) fused to EGFP under the CaMKIIa promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise optogenetic control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
BIOHIPPO AAV-hSyn-fDIO-Cre-mCherry-WPRE-hGH-polyA
Recombinant adeno associated virus expressing Cre fused to mCherry under the hSyn promoter with WPRE and hGH polyA elements. The Cre and Flp logic configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.